The coenzyme Q10 is a material without, which the body cells could not generate energy. Its antioxidant effect is indirect in contrast to the direct antioxidants like vitamins E and C and beta-carotene, which bind already formed free radicals.
Both types of antioxidants are complemented to defense the cell. The Q10, however, does not supply only with food, it can be synthesized by the organism. It is proved that after 20-th years, its quantity in cells gradually decreases, and its outgo at stress and huge load up growths, too.
From the other side, Q10 synthesizes in the body from the tyrosine amino acid. The synthesis process has 17 stages, which are regulated by several enzyme systems and requires the participation of seven vitamins: B2, В3, В5 (pantothenic acid), В6, В9 (folic acid), В12, С, and other microelements!!!
The ability of the body to fulfill the Q10 deficiency by the food is little, because its content in the regular foods, like meat, liver, etc. is poor. These products are categorically contraindicated for people with high blood cholesterol, ill from atherosclerosis, and other metabolic diseases. Then the alternative is additional intake.
The scientists combine 62 diseases with Q10 deficiency.
What is The Coenzyme Q10 Appliance?
For preventive: it is very essential for heart-vascular diseases (Q10 is so-called “heart vitamin), and also for immune system strengthening and for general organism health.
In complex healing: The investigations show its good influence and effectiveness at:
- ischemic heart disease and other heart-vascular diseases:
- at atherosclerosis
- hypertonic disease
- neurological diseases
- Hyper-function of the thyroid gland
- diabetes and liver and blood diseases
- slows up the aging process in the organism
- stimulates the immune system and organism adaptation reactions
- reduces the toxicity of antibiotics and anti-cancer preparations
Q10 is a fat-soluble substance and that is why the different commercial forms have to be taken with fatty food.
Coenzyme Q10 Food Sources
CoQ10 is observed in beef muscle and heart, chicken, pork, fish, and eggs. It is also found in smaller quantities in spinach, grains, broccoli, beans, nuts and corn, sesame, rapeseed, and soybean oils. Rice bran and wheat germ are also sources. There are also different kinds of supplementation available.
Highest food sources of CoQ10:
- Beef heart
- Soybean oil
- Rapeseed oil
- Beef liver
- Sesame oil
- Soybeans, roasted and ground
- Peanuts, roasted
- Sesame seeds, roasted
- Pork liver
Scientific Evidence on the Benefits of Coenzyme Q10
CoQ10 supplement is shown to bring the levels back to normal for those people who are lacking. Critical insufficiency in CoQ10 may lead to weakness, fatigue, and seizures.
Congestive Heart Failure (CHF) / Heart Failure:
Studies reveal that CoQ10, when mixed with other prescript medications to manage congestive heart failure (CHF), significantly improves the signs, decreases edema (swelling), shortness of breath (dyspnea), and insomnia.
High Blood Pressure (Hypertension):
Mixing CoQ10 with suggested blood pressure medications brings blood pressure down more than by just taking the prescription drugs alone. normally, taking CoQ10 lowers systolic blood pressure by 11 mm Hg and diastolic blood pressure by 7 mm Hg.
General studies show that taking CoQ10 supplements provides important health benefits for the heart and blood vessels, especially for those who have one or more risk factors (e.g. high blood pressure (BP), sugar, and high cholesterol).
Studies in human subjects recommend that Coenzyme Q10 may reduce the number and sharpness of migraine headaches in both children and adults. CoQ10 can decrease headaches by up to 30%. You may need to use CoQ10 for up to 3 months to see a benefit. However, a more recent well-designed clinical study showed that using CoQ10 along with standard therapy shows no added benefits.
HIV / AIDS:
There are clinical studies to show that taking CoQ10 improves the immune system in those experiencing HIV / AIDS.
Heart Attack (Myocardial infarction / MI):
A study carried in human subjects showed that taking CoQ10 within 3 days of a heart attack and remaining for one year decreased the risks of another severe heart event and possible death.
One clinical study showed that taking CoQ10 improved the levels of the “good cholesterol” (HDL) but it had no effect on the “bad cholesterol” (LDL).
Male Infertility / Fertility Enhancement:
There are numerous studies to show that CoQ10 supplements improve sperm count and motility. It is assumed that a higher intensity of CoQ10 in the semen may improve sperm role, leading to enhanced fertility.
Gum Disease (Gingivitis):
There is proof that people experiencing gum disease have lower blood levels of this essential vitamin-like substance.
Some people undergoing muscular dystrophy seem to perform better physically when they are taking CoQ10.
Angina (Chest Pain):
Taking CoQ10 may help with decreasing chest pain from angina.
Coenzyme Q10 Side Effects
Although studies have revealed that side effects of coenzyme Q10 (if they even occur) are not likely to be severe, you should contact your healthcare provider right away if you get fainting, allergic reactions, or signs of liver damage.
These severe side effects may intimate that you should stop taking the supplements. Other, less severe coenzyme Q10 side effects may include diarrhea, nausea, and loss of appetite.
Serious Side Effects of CoQ10
In general, studies have proved that coenzyme Q10 supplements are not likely to cause severe side effects.
However, based on stated side effects or academic problems that could happen, there is a figure of side effects with coenzyme Q10 that you should report to your healthcare provider. These side effects may also intimate that you should stop taking the supplement.
- Fainting or dizziness, which could be a sign of low blood pressure
- High liver enzymes (early studies recommended that coenzyme Q10 could raise liver enzymes, although later studies have not confirmed this)
- Signs of an allergic reaction, including itching, hives, unexplained swelling, wheezing, an unexplained rash, or difficulty breathing or swallowing.
Coenzyme Q10 Dosage and How to Take It
- 150 mg daily for known coenzyme Q-10 deficiency.
- 150-160 mg, or 2 mg/kg/day. In some situations, doses may be slowly increased to 3000 mg per day for mitochondrial disorders
- 100 mg per day divided into 2 or 3 doses for heart failure in adults:
- For decreasing the risk of coming cardiac events in patients with recent myocardial infarction: 120 mg daily in 2 divided doses.
- 120-200 mg per day divided into 2 doses for high blood pressure(BP).
- 60 mg twice daily for isolated systolic hypertension:
- For preventing migraine headaches: 100 mg three times daily. A dosage of 1-3 mg/kg has also been used in pediatric and adolescent patients.
- 300 mg, 600 mg, 1200 mg, and 2400 mg per day in 3-4 divided doses for Parkinson’s disease:.
- 200 mg per day for HIV/AIDS.
- 200-300 mg per day for infertility in men.
- For muscular dystrophy: 100 mg per day.
- 100 mg twice daily starting at week 20 of pregnancy until delivery for pre-eclampsia: